abstract：PURPOSE OF REVIEW:Frailty is the concept of accumulating physiologic declines that make people less able to deal with stressors, including surgery. Prehabilitation is intervention to enhance functional capacity before surgery. Frailty and prehabilitation among transplant populations and the role of wearable fitness tra...

journal_title：Current opinion in organ transplantation

authors： Rumer KK,Saraswathula A,Melcher ML

更新日期：2016-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The development of diffuse splanchnic venous thrombosis continues to be a challenging undertaking for patients waiting for liver transplantation, requiring the utilization of highly complex surgical techniques. The aim of this article is to review the status of multivisceral transplantation (MVT) in t...

journal_title：Current opinion in organ transplantation

authors： Vianna R,Beduschi T

更新日期：2016-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The Notch signaling pathway is known to play a pivotal role in T- and B-cell development and fate, presenting it as an attractive therapeutic target in alloimmunity. This review provides an overview of the mechanisms of Notch signaling, focusing on new insights into its diverse functions in T-cell act...

journal_title：Current opinion in organ transplantation

authors： Magee CN,Riella LV

更新日期：2016-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review summarizes current data on the induction of immunologic tolerance through mixed hematopoietic chimerism relevant to applying this approach to vascularized composite allotransplantation. RECENT FINDINGS:Clinical allograft tolerance has been achieved recently for kidney transplants, ...

journal_title：Current opinion in organ transplantation

authors： Cetrulo CL Jr,Drijkoningen T,Sachs DH

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we summarize the current status of clinical trials using therapeutic cells produced from human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). We also discuss combined cell and gene therapy via correction of defined mutations in human pluripotent stem ce...

journal_title：Current opinion in organ transplantation

authors： Angelos MG,Kaufman DS

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Pulmonary antibody-mediated rejection (AMR) while contributing to acute and chronic allograft dysfunction remains a diagnostic and therapeutic challenge. The diagnostic tenets upon which AMR is defined will be reviewed in the light of recent studies. RECENT FINDINGS:The introduction of solid phase as...

journal_title：Current opinion in organ transplantation

authors： Westall GP,Paraskeva MA,Snell GI

更新日期：2015-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Primary graft failure, which represents one of the most frequent causes of early mortality, is mostly caused by ischemia-reperfusion injury (IRI). IRI may also induce rejection, which is the principal cause of mortality after transplantation. It is essential to understand the mechanism of pulmonary IR...

journal_title：Current opinion in organ transplantation

authors： Chen F,Date H

更新日期：2015-10-01 00:00:00

abstract：PURPOSE OF REVIEW:B cells are known to play a central role in humoral immunity and to boost cellular immunity, however, in a variety of experimental models, B-cell subsets ameliorate inflammation and autoimmune disease, indicating that they can also play a regulatory role. Here, we highlight the advances in regulatory ...

journal_title：Current opinion in organ transplantation

authors： Kim JI,Rothstein DM,Markmann JF

更新日期：2015-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Burgeoning literature on antibody-mediated rejection (ABMR) has led to a perception that T-cell-mediated rejection (TCMR) is no longer a significant problem. This premise needs to be carefully appraised. RECENT FINDINGS:A review of the literature indicates that TCMR remains an independent-risk factor...

journal_title：Current opinion in organ transplantation

authors： Randhawa P

更新日期：2015-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the experience to date and unique challenges associated with liver transplantation in hepatitis C virus (HCV)/HIV-coinfected patients. RECENT FINDINGS:The prevalence of cirrhosis and hepatocellular carcinoma is rising among HIV-infected individuals. With careful patient selection and in the...

journal_title：Current opinion in organ transplantation

authors： Kardashian AA,Price JC

更新日期：2015-06-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we discuss the current state of donation after circulatory death (DCD). We define the DCD donor and describe the current protocols in management of the DCD patient. We then discuss current techniques in organ procurement of the lung and abdominal organs. RECENT FINDINGS:Although donat...

journal_title：Current opinion in organ transplantation

authors： Algahim MF,Love RB

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:There have now been a total of 32 face transplants done in the world since the first in Amien, France, in 2005. This procedure is moving from being considered experimental to being considered an accepted option for reconstruction in cases of severe facial disfigurement. RECENT FINDINGS:There have bee...

journal_title：Current opinion in organ transplantation

authors： Coffman KL

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent studies on the directed differentiation of human pluripotent stem cells report tissue self-organization in vitro such that multiple component cell types arise in concert and arrange with respect to each, thereby recapitulating the morphogenetic events typical for that organ. Such self-organizat...

journal_title：Current opinion in organ transplantation

authors： Little MH,Takasato M

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The role of T-cell exhaustion in the failure of clearance of viral infections and tumors is well established. There are several ongoing trials to reverse T-cell exhaustion for treatment of chronic viral infections and tumors. The mechanisms leading to T-cell exhaustion and its role in transplantation,...

journal_title：Current opinion in organ transplantation

authors： Thorp EB,Stehlik C,Ansari MJ

更新日期：2015-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Vascularized composite allograft (VCA) transplantation restores function and form following major soft tissue and musculoskeletal injury. Lifelong immunosuppression is necessary for graft function and survival but acute skin-targeted rejection episodes remain common. We review recent advances in skin ...

journal_title：Current opinion in organ transplantation

authors： Chadha R,Leonard DA,Kurtz JM,Cetrulo CL Jr

更新日期：2014-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Although the scarcity of clinical trials with de-novo immunosuppression has been typical over the last 2 years, several attempts have been made in drug conversion, dosing optimization, and bioequivalence. On the basis of recent clinical and animal studies, future directions of management and treatment...

journal_title：Current opinion in organ transplantation

authors： Wohlfahrtova M,Viklicky O

更新日期：2014-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Extensive research in murine transplant models over the past two decades has convincingly demonstrated the ability of regulatory dendritic cells (DCregs) to promote long-term allograft survival. We review important considerations regarding the source of therapeutic DCregs (donor or recipient) and thei...

journal_title：Current opinion in organ transplantation

authors： Morelli AE,Thomson AW

更新日期：2014-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To introduce the updated Banff schema for antibody-mediated renal allograft rejection and related revisions to definitions within this schema agreed upon during and immediately subsequent to the 2013 Banff Conference on Allograft Pathology. RECENT FINDINGS:The original Banff schema for diagnosis of a...

journal_title：Current opinion in organ transplantation

authors： Haas M

更新日期：2014-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Type 1 and type 2 diabetes mellitus represent a widespread metabolic disorder, related to autoimmune β-cell destruction and insulin resistance, leading to β-cell dysfunction, respectively, that are associated with severe chronic complications with irreversible multiorgan morphological and functional d...

journal_title：Current opinion in organ transplantation

authors： Calafiore R,Montanucci P,Basta G

更新日期：2014-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Fulminant hepatic failure (FHF) is one of the more dramatic and challenging syndromes in clinical medicine. Time constraints and the scarcity of organs complicate the evaluation process in the case of patients presenting with FHF, raising ethical questions related to fairness and justice. The challeng...

journal_title：Current opinion in organ transplantation

authors： Appel J,Vaidya S

更新日期：2014-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Recipients of pancreas transplantation bear the burden of chronic complications of diabetes, both microvascular and macrovascular. Pancreas transplantation provides the most effective method of glycemic and metabolic control. As transplantation provides immediate relief from acute complications of dia...

journal_title：Current opinion in organ transplantation

authors： Dunn TB

更新日期：2014-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Discuss the recent progress on the clinical use of mesenchymal stromal (stem) cells (MSC) in solid organ transplantation (SOT). RECENT FINDINGS:Tissue repair and immunomodulatory properties have been recognized for MSC obtained from different human tissues. MSC-based therapy has been proposed to redu...

journal_title：Current opinion in organ transplantation

authors： Pileggi A,Xu X,Tan J,Ricordi C

更新日期：2013-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The number of patients listed for lung transplantation largely exceeds the number of available transplantable organs because of both a shortage of organ donors and a low utilization rate of lungs from those donors. Two major innovations in recent years include the use of lungs from donations after car...

journal_title：Current opinion in organ transplantation

authors： Cypel M,Keshavjee S

更新日期：2013-10-01 00:00:00

abstract：PURPOSE OF REVIEW:A significant number of kidney transplantations in industrialized countries is currently performed over human leukocyte antigen (HLA) or ABO antibody barriers after living donation to encounter the increasing shortage of organs from deceased donors. Although patients with moderate titers of anti-A/B a...

journal_title：Current opinion in organ transplantation

authors： Becker LE,Süsal C,Morath C

更新日期：2013-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Maintenance of T-cell function and modulation of tolerance are critical issues in organ transplantation. The thymus is the primary organ for T-cell generation, and a preserved thymic function is essential for a self-tolerant diverse T-cell repertoire. Transplant procedures and related immunosuppressiv...

journal_title：Current opinion in organ transplantation

authors： Nunes-Cabaço H,Sousa AE

更新日期：2013-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Nonalcoholic steatohepatitis (NASH), obesity, and the metabolic syndrome are highly prevalent. NASH, a rare indication for liver transplantation in the early 1990s, is now the third most common indication. This review considers key aspects of the liver transplantation for NASH. RECENT FINDINGS:NASH i...

journal_title：Current opinion in organ transplantation

authors： Charlton M

更新日期：2013-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize current evidence supporting the existence of C4d-negative antibody-mediated rejection (AMR) in renal allografts, its potential to cause chronic graft injury, and whether histopathologic features of C4d-negative AMR differ from those of C4d-positive AMR. RECENT FINDINGS:Recently published...

journal_title：Current opinion in organ transplantation

authors： Haas M

更新日期：2013-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Ischaemic kidney injury occurs during organ procurement and can lead to delayed graft function or nonviable grafts. The innate immune system is a key trigger of inflammation in renal ischaemia. This review discusses the components of innate immunity known to be involved in renal ischaemic reperfusion ...

journal_title：Current opinion in organ transplantation

authors： Cheung KP,Kasimsetty SG,McKay DB

更新日期：2013-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Although living donor transplantation is considered an ethically acceptable undertaking for the purpose of saving another's life, its safety remains under investigation. RECENT FINDINGS:Although living donors undertake considerable medical risks for no direct medical benefit, the question remains whe...

journal_title：Current opinion in organ transplantation

authors： Gordon EJ

更新日期：2013-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an overview of currently available immunosuppressive strategies and novel therapeutic developments in pancreas transplantation. RECENT FINDINGS:From 1966 through 2012 more than 30 000 pancreas transplantations have been performed around the world with excellent patient and graft survival. ...

journal_title：Current opinion in organ transplantation

authors： Kimelman M,Brandacher G

更新日期：2013-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Travel-related diseases may be seen in transplant recipients after travel, after transplant tourism, and via transmission from blood and organ donors, augmented by recent increases in travel, migration, and globalization. Such infections include tuberculosis, Plasmodium (malaria), Babesia, Trypanosoma...

journal_title：Current opinion in organ transplantation

authors： Kotton CN

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:In June 2011 the US Food and Drug Administration approved belatacept (Nulojix; Bristol-Myers Squibb, Princeton, New Jersey, USA) for the prophylaxis of organ rejection in adult kidney transplant recipients. This review will discuss the use of belatacept for the prevention of acute rejection as part of...

journal_title：Current opinion in organ transplantation

authors： Wojciechowski D,Vincenti F

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The use of everolimus has recently emerged for solid-organ transplantation in children. This review gives an overview of the relevant studies and clinical trials involving the immunosuppressive effects of everolimus in child organ transplant. RECENT FINDINGS:The use of everolimus in pediatric organ t...

journal_title：Current opinion in organ transplantation

authors： Pape L,Ganschow R,Ahlenstiel T

更新日期：2012-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Cardiac allograft vasculopathy (CAV) is still one of the major causes of death following heart transplantation. Here, we review the recent advances in its prevention and treatment. RECENT FINDINGS:Preventive measures comprise control of classical risk factors, prophylaxis against cytomegalovirus, avo...

journal_title：Current opinion in organ transplantation

authors： Crespo-Leiro MG,Marzoa-Rivas R,Barge-Caballero E,Paniagua-Martín MJ

更新日期：2012-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Re-transplantation of the lung has come of age. Here, we wish to review the recent literature on the topic and discuss clinical implications. RECENT FINDINGS:Many large volume transplant centres routinely perform lung re-transplantation with satisfactory outcomes. The main indication is bronchiolitis...

journal_title：Current opinion in organ transplantation

authors： Warnecke G,Haverich A

更新日期：2012-10-01 00:00:00

abstract：:World Kidney Day on March 8th 2012 provides a chance to reflect on the success of kidney transplantation as a therapy for end-stage kidney disease that surpasses dialysis treatments both for the quality and quantity of life that it provides and for its cost-effectiveness. Anything that is both cheaper and better, but ...

journal_title：Current opinion in organ transplantation

authors： Garcia GG,Harden P,Chapman J,World Kidney Day Steering Committee 2012.

更新日期：2012-08-01 00:00:00

abstract：PURPOSE OF REVIEW:In spite of impressive improvements in short-term outcomes for intestine transplant recipients, late allograft loss continues to plague the field. Attention has mostly been focused on T-cell-mediated cellular mechanisms of allograft rejection to explain these losses; however, as in other forms of soli...

journal_title：Current opinion in organ transplantation

authors： Dick AA,Horslen S

更新日期：2012-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The review will discuss the current pathological criteria for the diagnosis and classification of antibody-mediated rejection (AMR) in the cardiac allograft. RECENT FINDINGS:Until recently, the diagnosis of AMR required clinical dysfunction, presence of donor specific antibodies and pathological alte...

journal_title：Current opinion in organ transplantation

authors： Berry GJ

更新日期：2012-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Macrophages are members of the innate immune response. However, their role in the adaptive immune response is not known. The purpose of this review is to highlight our current understanding of macrophage structure and function and how they may participate in allograft injury. RECENT FINDINGS:Studies ...

journal_title：Current opinion in organ transplantation

authors： Mannon RB

更新日期：2012-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Memory T cells have emerged as a major threat to transplant survival; they are well equipped and well positioned to respond to antigens in an accelerated fashion. They participate in transplant rejection and resist interventions that usually contain naïve T cells. Thus, the means to prevent memory T c...

journal_title：Current opinion in organ transplantation

authors： Valujskikh A,Li XC

更新日期：2012-02-01 00:00:00